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Consequently, the composition and functional state of -cell subpopulations are likely key determinants of the efficacy for both microbiota-targeted and incretin-based interventions

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Additionally, despite the absence of pathogenic infections, acutely malnourished children exhibit elevated concentrations of IFN-, IL-6, and IL-1, indicating persistent, low-grade systemic inflammation, which may play a crucial role in non-communicable disease conditions including diabetes, cardiometabolic disorders and other diseases of the metabolic syndrome [112, 120, 121]