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Mol Pharmacol 55:263268 [DOI] [PubMed] [Google Scholar] Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, et al

(2005) Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

Every 10C temperature increase roughly doubles degradation speed

Couto, N., Wood, J., & Barber, J

These results suggest that signaling through MOR may be desensitized through a heterologous mechanism by receptor tyrosine kinase activation and that this mechanism may have important implications for pain control following tissue injury

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