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13 In the PIONEER-6 study, which compared oral semaglutide to placebo, retinopathy or adverse events related to DR occurred in 7.1% of semaglutide and 6.3% of placebo subjects

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Despite this broad therapeutic interest, certain domainsparticularly skeletal muscle biology and neurodegenerationillustrate a recurring translational mismatch between mechanistic signaling effects and clinical functional outcomes

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