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A recent paper using the zebrafish tailfin regeneration model demonstrated that Sonic hedgehog (Shh) a key signalling protein in the hedgehog signalling cascade acted downstream of NOX to increase SOD activity and H 2 O 2 production in the early stage of tailfin regeneration, most likely due to SOD oxidation 130

Inducible NOS (iNOS) is known as one of the main enzymes involved in the mitochondrial lipid peroxidation and in neuropathy

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Luo J., Mills K., le Cessie S., Noordam R., van Heemst D

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On top of lost efficacy observed with oxidized nebulized GSH, it can actively increase airway irritation