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In a meta-analysis there were no differences in the effect of intermittent fasting and continuous energy restriction on HbA 1c , with intermittent fasting having a modest effect on weight (1.70 kg) [79]

And what should you realistically expect

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The use of second-line ADMs was commonly accompanied by insulin or metformin in 80-90% of cases

Even if the impact would be bigger than that, I think over a 10-year period, it will be manageable, and we will have adequate lead time to adjust and prepare for any changes that we see. On a more practical note, he said, Obesity rates around the world are very different, and we have one of the lowest exposures since 75% of our sales come from outside of the US and 40% of our sales are in emerging markets [where average BMIs are far lower]

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