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Tirzepatide's longer track record in real patients provides greater confidence in its safety profile

Qiu Y, Ahn B, Sakurai Y, Hansen CE, Tran R, Mimche PN, Mannino RG, Ciciliano JC, Lamb TJ, Joiner CH, Ofori-Acquah SF, Lam WA (2018) Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

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In a tissue-repair model that requires both revascularization and cellular ingress (tendon, muscle crush, dermal wound), the two mechanisms are mechanistically additive rather than redundant