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If the pain improves after passing gas or is accompanied by bloating, it is likely related to digestive pressure

Falzone ME, MacKinnon R

13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

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Those who do not come off will likely trade the NASH for osteoporosis and sarcopenia later in life, unless again serious lifestyle changes occur