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For principal component analysis (PCA), counts of each cell group/mouse for each genotype where extracted and analyzed using DESeq2 129

Fatigue may occur because the body is adjusting to treatment, but it may also reflect under-eating, low protein intake, dehydration, electrolyte changes, rapid weight loss, poor sleep, constipation, low blood sugar, low blood pressure, or another medical issue

This ensures the safe and effective administration of the vitamin

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It is noteworthy that activating point mutations across any of the components of the pathway have been known as either trigger of cancer (mutations of RAF and RAS family genes) or as poor prognosis indicator (mutations of ERK and MEK) [114, 116]