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Method Google Scholar and PubMed were searched on various dates between December 2016 and March 2017

Although several studies have demonstrated the efficacy of RSL3 in various animal models (32), non-specific effects of RSL3 cannot be excluded given its poor bioavailability in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population (33)

We validated the assays with known radioprotective drugs, including WR-1065, the active metabolite of Amifostine, the only FDA-approved preventative therapy for radiation-induced xerostomia 14,15,59

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Its important for researchers to note that during initial phases of exploring GHK-Cu, an observed phenomenon sometimes referred to as purging or a temporary worsening of skin condition may occur

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