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Smith RG, Henry YK, Mattson MP, Appel SH

Semaglutide helps regulate your blood sugar levels and reduces appetite, which can lead to eating fewer calories

At a separate -arrestin recruitment pathway at GLP-1R, reta E_max = 40% of native (partial / biased agonism), tirzepatide partial in the same direction, semaglutide full at both pathways

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The best tolerated resin is colesevelam

Historically, a concern with many medications to treat diabetes was that they led to weight gain as a side effect