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Even in the absence of DHODH, high concentrations of brequinar were shown to effectively induce ferroptosis in Pfa1 cells derived from GPX4-deficient mouse fibroblasts

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Microfocused ultrasound with visualization (MFU-V) targets multiple skin layers and the SMAS with ultrasound energy

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This indicates poorer gout management focused on temporary relief from symptoms associated with recurrent flares, rather than long-term prevention of urate crystal deposition or joint damage