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Am J Med Genet C Semin Med Genet 2017
Here are the most frequent ones: Shaking the vial
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it's about preserving the integrity of complex amino acid chains to ensure your study's data is valid and reproducible
As children with SMA may have a limited carnitine synthetic capacity due to significantly diminished skeletal muscle mass, and VPA is known to inhibit carnitine transport and deplete carnitine levels by binding to VPA metabolites, we elected to combine VPA therapy with sufficient supplemental carnitine to avoid concerns about a confounding effect of carnitine depletion
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