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RLS represents a prevalent neurological comorbidity in hemodialysis patients, demonstrating significant associations with impaired sleep architecture and elevated the risk of cardiovascular diseases and mortality [80, 81]

In our office, we use physician-guided treatment plans through Lilly Direct, including brand-name medications, lab monitoring, progress tracking, and ongoing follow-up to help prioritize both safety and long-term success

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene

This entire process prevents the cell from producing misfolded or altered proteins.[ref] Studies show that high homocysteine levels cause ER stress and activate the unfolded protein response pathway, which can lead to cell death

Common effects include nausea, vomiting, diarrhea, and constipation, most of which resolve within 1-2 weeks or improve with slow dose titration

Even low-normal B12 levels can result in deficiency symptoms