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The formation of brown/black pigments is normally stimulated by melanocyte-stimulating hormone (MSH) binding to MSH receptor, which is a G-protein receptor coupled to Gs

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Tuesta LM, Chen Z, Duncan A, Fowler CD, Ishikawa M, Lee BR, et al

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Gluten and the Blood-Brain Barrier: The inflammatory reaction to gluten deteriorates the thin lining that protects the brain from pathogens and environmental toxins