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The mechanism requires active lipolysis (fat breakdown), which occurs when energy intake is below expenditure, not from the lipotropic compounds themselves

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As proposed in RLS, a loss of A-11 dopaminergic inhibition results in increased sensory input to cortex (uncomfortable sensations or urge to move), increased sensory activation of the spinal cord reflex arc (#3) (causing PLMS), and increased sympathetic activity (#2) (accentuating PLMS and associated medical conditions such as hypertension and pro-inflammatory states)