Intranasal BBB bypass is a validated human pharmacological route actively used for other biologics (e.g., intranasal oxytocin and insulin)
Abnormally regulated homeostasis of enzymes results in mitochondrial dysfunction, eNOS uncoupling, formation of secondary ROS, and disturbed metabolism of redox and non-redox active metals
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10.1055/s-2008-1066181 10
However, individuals with pre-existing liver disease should consult their hepatologist before supplementing, as altered metabolism could affect glutathione clearance