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There is growing awareness that we need to consider social determinants of health no matter what the topic, whether it be type 2 diabetes prevention, type 2 diabetes treatment, obesity treatment, type 1 diabetes prevention or use of technology

These factors coordinate transformation of precursor cells into mature contractile fibers

doi: 10.1016/j.jcjd.2019.09.003 110 HusainMBirkenfeldALDonsmarkMDunganKEliaschewitzFGFrancoDRet al

UPR is a highly conserved pathway that monitors endoplasmic reticulum (ER) proteostasis, allowing cells to manage ER stress (Moncan et al., 2021)

This toxic metabolite can bind covalently to proteins and cause cell necrosis

doi: 10.1016/S0306-4522(96)00434-4 140 DruckerDJAsaS