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D-pad The D-pad (short for directional pad ) is a compact input method developed for video games, designed to translate thumb movement into directional control through a flat, cross-shaped surface that rests on four internal switches

Dopaminergic pathways are similarly affected, with reduced tyrosine hydroxylase activity leading to diminished dopamine in the basal ganglia and prefrontal cortex, manifesting as anhedonia, reduced motivation, and psychomotor retardation (73, 74)

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372,373 The mTOR pathway plays a significant role in DPN development by affecting autophagy and apoptosis in Schwann cells, myelin formation, and lipid metabolism, thereby influencing myelin and axonal integrity