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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

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LIKE ANY ACTIVE PRODUCT, THIS MEDICATION CAN, IN SOME PEOPLE, CAUSE MORE OR LESS TROUBLESOME EFFECTS: Allergic reactions in particular: itching, eczema, urticaria, skin redness, edema that may be severe, intense generalized malaise

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Nearly 75% of enrollees with diagnosed substance use disorders utilized some treatment services in 2020, with higher participation in outpatient and medication-assisted treatment compared to residential programs