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Under continuous weekly exposure the receptor desensitizes: semaglutide is a full beta-arrestin recruiter (GLP-1R Emax 106%, Coskun 2022 Table S2

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Once activated, this pathway encourages pulsatile GH release , leading to a downstream increase in Insulin-like Growth Factor 1 (IGF-1) production from the liver a key anabolic hormone responsible for muscle growth, fat metabolism, and cellular repair

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