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Greenbaum, C

Studied in exercise, body composition and metabolic contexts, it shows variable, generally modest effects

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doi: 10.1158/1078-0432.CCR-12-1308

Notably, the molecular events triggered by TMAO disrupt endothelial integrity by reducing the expression of tight junction proteins Zonula Occludens-2 (ZO-2) and Occludin (OCLN), while decreasing phosphorylated endothelial nitric oxide synthase (p-eNOS), thus increasing endothelial permeability and allowing LDL to enter and oxidize to ox-LDL [113, 114]