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This is a known side effect that can vary in intensity among individuals

In clinical practice, TC concentration is used to stratify cardiovascular risk using the SCORE scale and to assess the severity of hypercholesterolaemia (suspected familial hypercholesterolaemia) and as the basis for therapeutic decisions in the absence of LDL-C calculation/test results (very rarely at present) [9, 65, 66]

[PubMed: 7058085] 5

The choice of suitable linker chemistry is often based on intuition, but the significant pH difference between endosomes and the extracellular space (pH 2) makes it easier to achieve selective release