This has generated enormous demand: patients and prescribers use GLP-1s for obesity management and related metabolic disorders
Black adults report the highest usage of GLP-1 medications among racial and ethnic groups, at 18%, followed by Hispanic adults at 13%
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However, it is best to avoid prolonged exposure to water or intense heat
This is rarely the compound patent and often a formulation, method-of-use, or pediatric exclusivity extension
Most common side effects (12mg dose, across TRIUMPH-4 and TRIUMPH-1): Nausea: 43% TRIUMPH-4 / ~38% TRIUMPH-1 (mostly during dose escalation) Diarrhea: 33% / ~28% (peaks weeks 48, improves by week 16) Dysesthesia: 20.9% (tingling sensations onset variable, long-term persistence unknown) Vomiting: 21% / ~25% (decreases after month 3) Constipation: 25% Discontinuation rates: 18.2% in TRIUMPH-4 (osteoarthritis population), 11.3% in TRIUMPH-1 (general obesity population)