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To investigate the efficacy of semaglutide on the metabolic and inflammatory features, post-baseline changes were analyzed using an MMRM, with baseline diabetes status, baseline fibrosis stage and diabetes-by-fibrosis interaction as factors (HbA1c, fasting plasma glucose, homeostatic model assessment of insulin resistance, adipose tissue insulin resistance and non-high-density lipoprotein cholesterol could not be included in the diabetes-by-fibrosis interaction as factors) and baseline body weight and baseline value of the feature as covariates, all nested within visit

To facilitate quantification of GSH, additional spectra were collected from the same volume of interest (Figure 4) using a short-echo PRESS sequence with vapor water suppression (repetition time=2,000 ms, echo time=36 ms

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