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Moreover, oxidative stress makes the kidney tissue susceptible to damage by various alterations including the promotion of lipid peroxidation, protein modification, and DNA damage, leading to cell death [14]

The results suggest that the peptide is potentially safe for treating obesity

Participants receiving multiple ascending doses of AMG133 experienced sustained weight loss for up to 150 days after the last dose (84)

One mechanism involves the direct oxidation of key cysteine residues in kinases or phosphatases [68]

The effectiveness of the drug extends even to East Asian populations, which shows that it has superior weight reduction and a decrease in abdominal visceral fat

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