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Liraglutide treatment increased the percentage of bihormonal insulin + glucagon + cells relative to the total number of insulin- and glucagon-expressing cells per islet in WT mice but not in KO mice (Figure 6, A and B

10.7759/cureus.50725 Cureus

Without timely identification and treatment, the risk of complications and disease progression increases significantly

They are the reason the schedule is a guide, not a mandate

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Missing doses or irregular use can reduce effectiveness and potentially increase side effects when restarting