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Biliary disease was numerically higher, but did not achieve statistical significance in the primary analysis (aHR 1.5, 95% CI: 0.9-2.5)

Ozempic has a half-life of approximately one week, providing relatively stable blood levels

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Dose reduction or temporary treatment interruption, followed by slower re-titration, often allows continued therapy with improved tolerance

The FDA explains drug development and approval basics: FDA drug development process

Retatrutide is titrated from 1 mg up by 4-week steps (1 2 4 6 9 mg), with 12 mg as the maximum tested dose