It is not equivalent to proof of safety, especially because ketone surveillance, event adjudication, and adverseevent capture were not standardized across studies
Cardiovascular - Frequent: tachycardia, postural hypotension, hypotension Infrequent: hypertension, bradycardia, edema (extremities), angina pectoris, extrasystoles, cardiac failure, flushing, myocardial infarction, cerebrovascular accident, myocardial ischemia Rare: transient ischemic attack, phlebitis, atrial fibrillation, cardiac arrest, bundle branch block Central and Peripheral Nervous System Disorders- Frequent: paresthesia, migraine Infrequent: hyperkinesia, vertigo, hypertonia, extrapyramidal disorder, leg cramps, involuntary muscle contractions, hypokinesia, neuralgia, dystonia, abnormal gait, hypesthesia, ataxia Rare: abnormal coordination, hyperesthesia, ptosis, stupor Endocrine Disorders - Rare: hypothyroidism, goiter, gynecomastia Gastrointestinal Disorders - Frequent: saliva increased, flatulence Infrequent: gastritis, gastroenteritis, stomatitis, eructation, hemorrhoids, dysphagia, teeth grinding, gingivitis, esophagitis Rare: colitis, gastric ulcer, cholecystitis, cholelithiasis, duodenal ulcer, gastroesophageal reflux, glossitis, jaundice, diverticulitis, rectal hemorrhage, hiccups General - Infrequent: hot flushes, rigors, alcohol intolerance, syncope, influenza-like symptoms Rare: hay fever
That approach protects both areas and keeps absorption consistent over time
Rosenwald M, Perdikari A, Rulicke T, Wolfrum C
Nhng Glutathione c phi l mt cht an ton
The patients in the trial also saw nearly 20% weight loss during the 52 weeks
