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This leads to promoter silencing of several genes, such as adenomatous polyposis coli (APC), cyclin-dependent kinase inhibitor-2 (CDKN-2), breast cancer susceptibility gene 1 (BRCA1), retinoblastoma protein (Rb), and murine double minute 2 (MDM2), and the DNA mismatch repair gene, human mutL homolog 1 (hMLH1) [96, 97]

Wang HH, Portincasa P, Wang DQH (2006) Prevention of cholesterol (Ch) gallstones by the potent Ch absorption inhibitor Ezetimibe in gallstone-susceptible mice

Large-scale CQD synthesis is often hindered by batch-to-batch variability, impurity profiles, and contamination risks, emphasising the need for standardised, GMP-compliant synthesis protocols and robust quality control frameworks [178]