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Treating drug addiction and preventing relapse with ghrelin antagonists There is now substantial evidence suggesting that GHSR located in the mesolimbic dopaminergic system is associated with the amplification of reward-seeking behaviors, including those associated with drugs of abuse (Abizaid, 2009

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Epigenetic alterations, including decreased DNA methylation and modified histone marks (H3K9, H4K12), further compromise oocyte quality and meiotic progression [99]

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Jenniskens M, Guiza F, Oorts M, Vander Perre S, Derde S, Dufour T, et al