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Due to their remarkable ability to regulate metabolism, they have been widely adopted in the management of type 2 diabetes mellitus (T2DM) and obesity

Semaglutide and tirzepatide have FDA-approved prescription uses under specific brand names and indications

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Retatrutide targets three hormone receptors (GLP-1, GIP, and Glucagon) simultaneously, and this broader mechanism may explain why skin-related reactions appear more often compared to single-receptor treatments

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