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Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives

Watanabe, A., Okada, K., Shimizu, Y., Wakabayashi, H., Higuchi, K., Niiya, K.,

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In the model, treatment with a MO methanolic extract markedly reduced the serum concentration of C-reactive protein, prostaglandin E2, and TNF, markedly downregulated the levels of NF-B, prostaglandin E2 (PGE2), cyclooxygenase 2 (COX-2), and IL-1, and significantly upregulated the mRNA levels of I-B , IL4 , and IL-10 , and remarkably restored the histopathological indices and arthritic index in the joints (Saleem et al., 2019)

The HDAC1 inhibitor Entinostat (MS-275) is considered the most potent hepcidin agonist