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25 A nerve biopsy of the first known patient with the ACOX1 N237S mutation revealed a loss of Schwann cells

Acknowledgements This work was supported by the National Natural Science Foundation of China (grant # 81971256 [to HX]) and Natural Science Foundation of Guangdong Province (grant # 2016A030313067 [to HX])

(2024, November 8)

Collectively, the gut microbiota dysbiosis mediated by these specific bacterial populations may jointly promote the occurrence and progression of OA through multiple pathways such as regulating the hosts immune-inflammatory response, metabolic disorders, and oxidative stress, providing novel targets and strategies based on gut microbiota regulation for the prevention and treatment of OA