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When a drug is in shortage, federal law under sections 503A and 503B of the Food, Drug and Cosmetic Act permits licensed compounding pharmacies and outsourcing facilities to compound drugs that would otherwise be considered an unapproved copy of an FDA-approved product - an exemption that allowed the compounded GLP-1 telehealth industry to scale significantly between 2022 and 2024

The counterintuitive read on this data is that the patients most likely to benefit metabolically those with severe obesity and long-standing insulin resistance may carry the highest psychiatric risk from central GLP-1 agonism

However, the risk increases during transition age and adulthood follow-up, especially when other risk factors coexist [300]

With expert advice, many patients see improvements over time, leading to better results [1]

So what happens when your medication has lost 20%, 40%, or even 60% of its potency

& Morris, M