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It is important to note that confirmation of ferroptosis in erythrocytes can be challenging due to the impossibility to assess characteristic alterations of organelles (especially mitochondria, absent in mature RBCs) and the complex ferroptosis signaling requiring epigenetic, transcriptional, and post-translational regulation

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Authors contributions LT, WW, WZ and KC performed the experiments

For more severe joint issues, injectable collagen formulations like ChondroGrid have shown promise, with significant improvements in pain, stiffness, and function after just 30 days in knee osteoarthritis patients

Collagen decreases in the body with age, showing visible signs in your skin, which becomes less firm and supple