It shuts it down
Lets break down what fatigue actually is, why GLP-1s can make you feel like your energy was unplugged from the wall, and what you can do to feel more normal again
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GLP-1 (Glucagon-like peptide-1) injections are a class of medications that mimic the action of the natural GLP-1 hormone in the body, stimulating insulin secretion, suppressing appetite, and delaying gastric emptying, thereby promoting weight loss
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The type 2 IGF receptor (IGF-2R / cation-independent mannose-6-phosphate receptor) does not signal in the classical sense but acts as a clearance sink for IGF-2 and, to a lesser extent, participates in ligand disposal