References Int J Mol Sci (MDPI) Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (2025) PMC/Biogerontology Epitalon increases telomere length in human cell lines through telomerase upregulation Neuroendocrinology Letters (PubMed) Synthetic tetrapeptide Epitalon restores neuroendocrine regulation in senescent monkeys Bull Exp Biol Med (PubMed) Geroprotective effect of epithalamine in elderly with accelerated aging (12-year RCT) Alzheimers Drug Discovery Foundation Epithalamin/Epithalon Cognitive Vitality Report (mechanisms, dosing, safety) JPT Peptide Technologies Peptide Stability: How Long Do Peptides Last
median follow-up: 3.0 years), demonstrated that finerenone reduced cardiovascular events by 14% (HR 0.86
While the difference was not dramatic (~3 points, which is well below the minimally clinically important difference in the MDS-UPDRS-3 of around ~5 points), it appeared to remain after a 2-month washout period, intended to support the idea that, because the improvements remained after removal of the incretin, the difference should be a disease-modifying, rather than a symptomatic benefit
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