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Description

Most GI symptoms resolve by week 12 in approximately 75% of patients for both medications

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Researchers should establish and document a fixed weekly injection day and approximate time of day for each study subject to facilitate steady-state pharmacokinetic modeling

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In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)

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Think of them as signaling molecules small strings of amino acids that tell tissues to repair, regenerate, or dampen inflammation

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Starting at a lower initial dose (for example, 2 mg instead of 4 mg) also helped partially reduce these GI symptoms, andas with other GLP-1 medicationsthe dose was gradually increased over time to improve tolerability

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