In this follow-up, were going to look specifically at tirzepatide, one of the more recent and most popular GLP-1 agonists
While the combination therapy did not outperform the placebo, GLP-1 on its own showed a statistically significant improvement in liver scarring without worsening underlying liver inflammation, even among patients with the most advanced disease
10m-sections were cut on a cryostat (Leica Biosystems) and collected on SuperFrost Plus slides, then air-dried at room temperature for 1 h followed by incubation at 40 C for 5 min
Weekly dosing schedules have also improved adherence compared to older daily regimens
Although, most participants lost weight, there was heterogenicity, that has been well-documented in obesity studies [66] and those with higher BMI above 35 experienced greater mean percentage weight loss [64]
Women carrying certain variants may experience more pronounced weight regain during pregnancy or faster weight loss postpartum, patterns that affect treatment planning across the reproductive lifecycle
