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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

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However, the median t was shorter than in the present study (6.25 h, range 4.5910.6 h) [5]

Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network