2079 20013 (AIP Publishing LLC, 2019)
10.3389/fpsyt.2020.00541 28 BaratiM.GhahremaniA.Namdar AhmadabadH
Analysis of Denmarks comprehensive diabetes database demonstrated: Analysis of all 424,152 Danish citizens with Type 2 diabetes between 2018 and 2024 106,454 patients exposed to once-weekly semaglutide versus 317,698 unexposed Hazard ratio of 2.19 (95% CI, 1.54-3.12) for NAION development More than doubling of five-year NAION risk among semaglutide users Consistent findings across multiple sensitivity analyses A parallel Danish-Norwegian cohort study examining 61,377 semaglutide users found similarly concerning results, with an adjusted hazard ratio of 2.81 (95% CI 1.67-4.75) when compared to SGLT-2 inhibitor users
Wegovy also has an FDA approval for cardiovascular risk reduction (March 2024), which makes it attractive for coverage
Urine testing is also the most commonly used format for probation monitoring, pre-surgical workups that include a substance screen, and return-to-duty testing in regulated industries
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