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In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression

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To our knowledge, this is the first time of the founding of that maternal HMSeBA supplementation regulating ER stress signal of the offspring intestine, whats more, synergistic regulations of GPX4 and SELS can also protect IPEC-J2 cells against ER stress in vitro

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