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Both GPX1 expression and activity were substantially lower in mice fed a selenium-deficient diet than those in mice fed a normal diet, leading to decreased trabecular number, reduced femoral trabecular volume/total bone volume ratio, and trabecular separation 66

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In summary, the core breakthrough in current HIF-targeted drug development lies in establishing the regulation of ROS generation (inhibiting pathological accumulation or controllably utilizing its killing effect) as the key hub for intervening in hypoxia-related diseases

Toll-like receptor 4 in acute kidney injury