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Given that HD affects different regions of the brain, its typical clinical manifestations include motor and cognitive disorders, as well as mental and behavioral abnormalities

All cell lines were authenticated via short tandem repeat (STR-10) profiling and regularly tested for mycoplasma contamination and tested negative via the Duke Cell Culture Facility (CCF), now known as the Duke Life Science Facility (LSF)

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Importantly, the protective effects required adipose-specific knockdown establishing adipose tissue as a primary target organ for NNMT-inhibition research in metabolic contexts

This protective role contributes to strengthening our immune system