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Indeed, patients who were originally described as suffering from deficiencies in the LCAD enzyme were, in fact, found to be harboring pathogenic variants in the ACADVL gene which encodes the VLCAD enzyme

19 In contrast, other studies have shown that 89% of erythrocyte glutamate was derived from alanine aminotransferase (ALT), 22 and that -ketoglutarate availability was more important than glutamine when RBCs were depleted of GSH

The neuroprotective role of estrogens implies a close regulation of processes such as (i) anti-oxidant activity (Kumar et al., 2010), (ii) DNA repair (Scharfman and MacLusky, 2006), (iv) synaptic plasticity (McEwen and Milner, 2007), and (v) the blood flow to the brain (Zhao and Brinton, 2006

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