Supplementation with -KG effectively reverses the decrease in cFLIP levels caused by the inhibition of Gln breakdown and enhances resistance to TRAIL ( 2.1.3 Induction of an immunosuppressive microenvironment Gln is a conditionally essential amino acid crucial for the metabolism of both tumor and immune cells
Curie A, Touil N, Gaillard S, Galanaud D, Leboucq N, Deschenes G, Morin D, Abad F, Luaute J, Bodenan E, Roche L, Acquaviva C, Vianey-Saban C, Cochat P, Cotton F, Bertholet-Thomas A (2020) Neuropsychological and neuroanatomical phenotype in 17 patients with cystinosis
Modis, K., Ju, Y., Ahmad, A., Untereiner, A
Traditional glutathione supplements are often degraded in the digestive tract, limiting their effectiveness
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Journal of Cellular and Molecular Medicine 14(10):23812392