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Psychiatric safety of semaglutide for weight management in people without known major psychopathology: post hoc analysis of the STEP 1, 2, 3, and 5 trials

However, many subgroup differences were not statistically significant, and results should be interpreted with caution given the limited number of included studies for several analyses

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These modifications confer an extended elimination half-life of approximately 116.7 h, facilitating once-weekly dosing

This creates an individualized optimization challenge: finding the lowest dose that produces satisfactory results while minimizing adverse effects