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We have systematically summarized the effects of exercise on ferroptosis regulation through multiple molecular mechanisms, including upregulation of antioxidant defense systems via activation of NRF2, GPX4, and SLC7A11 signaling pathways

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Zou Q, Zhou X, Lai J, Zhou H, Su J, Zhang Z, Zhuang X, Liu L, Yuan R, Li S, et al

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Sestrins, which have long been linked to protection from oxidative stress, were found to interact with p62 and KEAP1 to promote KEAP1 autophagic degradation [86]

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