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Persistent ROS generation or electrophilic stress can oxidize GSH to GSSG more rapidly than it is reduced, thereby depleting the reduced thiol pool

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The treatment approach should be individualized: Pharmacotherapy for all eligible patients with stage 2 or 3 fibrosis (including lean patients) Metabolic-bariatric surgery for those meeting body mass index criteria, and Endoscopic options for patients seeking alternatives to metabolic-bariatric surgery who can manage the out-of-pocket costs

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Testosterone continues to support muscle preservation and growth while semaglutide reduces caloric intaketogether, they create ideal conditions for fat loss while maintaining lean mass